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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Jul 16;29(10):1444–1451. doi: 10.1161/ATVBAHA.109.193086

Figure 4. Microscopic mapping of probe activation.

Figure 4

Immunofluorescence microscopy of cathepsin B presence (green, emission 620nm), DAPI-stained DNA in cell nuclei (blue, emission 460nm) and protease sensor activation (red, emission 700nm) shows colocalisation in atherosclerotic plaques (yellow, arrows). Left panel shows histology from apoE−/− mouse injected with PS-5, middle PS-25, and right PS-40. The error bar denotes 50µm.