. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Apr 16;29(10):1424–1432. doi: 10.1161/ATVBAHA.108.180521

Table 3.

Differential expression of biomarkers in subsets

Biomarker	Cell type (mouse)	Cell type (human)	Function
CD14	ND	CD14⁺CD16^lo	Receptor for detection of bacterial lipopolysaccharide
CD16	ND	CD14^loCD16^hi	Fcy receptor binds to Fc portion of IgG antibodies
CCR2	Ly-6C^hi	CD14⁺CD16^lo	A chemokine receptor that promotes recruitment of Ly-6C^hi monocytes to lesions in mice
CX₃CR1	Ly-6C^lo > Ly-6C^hi	CD14^loCD16^hi > CD14⁺CD16^lo	A chemokine receptor that has surprisingly been reported to promote recruitment of Ly-6C^hi, but not Ly-6C^lo, monocytes to lesions
Cathepsins	Ly-6C^hi > Ly-6C^lo	ND	Proteolytic enzymes that remodel the extracellular matrix and decrease stability of plaques
MMPs	Ly-6C^hi > Ly-6C^lo	ND	Proteolytic enzymes that remodel the extracellular matrix and decrease stability of plaques
MPO	Ly-6C^hi > Ly-6C^lo	ND	An oxydant-generating enzyme that promotes inflammation and plaque formation and destabilization

ND, either differences between subsets have not be determined or no clear species conservation of antigens