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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Jul 16;29(10):1644–1650. doi: 10.1161/ATVBAHA.109.191965

Figure 6. S1P releases calcium from intracellular stores in a S1P2R-dependent manner.

Figure 6

Calcium transients were measured in quiescent wild-type and S1P2R-null SMCs following stimulation with 1 µmol/L S1P or 10 ng/mL thrombin and quantified by measuring peak height after setting the baseline to 1. Data are presented as mean +/− S.D., n=10–12, *P<0.05. (A) Quiescent wild-type cells were pretreated with BAPTA-AM (BA), nifedipine (Nif), thapsigargin (TP), or C3 as described for Fig. 4 before S1P stimulation. Data are presented as mean +/− S.D, n=4–8, *P<0.05 (drug-treated vs. control, Bonferroni adjustment was applied).