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Hyperinsulinemic euglycemic clamp studies were conducted to calculate (A) Ginf, (B) GDR, (C) HGO, and (D) GDR normalized to fat pad mass as a percent of body weight in WT (black bars) and 12/15LO KO (gray bars) mice fed NC or two-week HFD. Values are mean±standard error. 7–9 animals per group. *p<0.05 vs WT HFD, #p<0.05 vs WT NC.
