Figure 7. Masitinib inhibits tumour growth in vivo.

Nude mice were gamma-irradiated and after 24 hours, injected subcutaneously with 1.5×10⁶ Ba/F3 cells expressing the murine Δ27 KIT mutant. (A and B) Effect of intraperitoneal administered masitinib treatment on Δ27 KIT-expressing tumours, with an average pre-treatment tumour volume of 400 mm³ (large tumour experiment). Mice were treated with 30 mg/kg masitinib or a placebo (vehicle control) (n = 10 per group) twice daily for 25 days by intraperitoneal injection. (A) Mean tumour volume assessed every 5 days during the treatment. D19 corresponds to the first day of treatment. (B) Kaplan-Meier survival plot. (C) Effect of oral masitinib treatment on Δ27 KIT-expressing tumours, with an average pre-treatment tumour volume of 40 mm³ (small tumour experiment). Mice were treated twice daily for 11 days with masitinib administered orally at 0 (controls), 10, 30, or 45 mg/kg. D14 corresponds to first day of treatment.