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Levels of S-adensylmethionine (AdoMet; a, d) and S-adenosylhomocysteine (AdoHcy; b, e) and the methylation index (AdoMet/AdoHcy; c, f) in brain tissue of 8- and 15-month-old APP/PS1 mice and their wild-type littermates. 8-month-old wild-type mice n = 16, 8-month-old APP/PS1 mice n = 19 15-month-old wild-type mice n = 28, 15-month-old APP/PS1 mice n = 19. Values represent mean and SEM. * p < 0.01
