Figure 2.

Radiotracer uptake in the aorta by ex vivo imaging and quantitative estimates of Tc-MPI and In-AA5%ID/g uptake. A Ex vivo images of explanted aortas of the different study groups (control; HC diet; diet withdrawal; fluvastatin) are displayed. Each column shows two images of the same aorta; In-AA5 (right) and Tc-MPI (left). Intense uptake of Tc-MPI and In-AA5 within the abdominal aortas of rabbits on uninterrupted HC diet is observed. The uptake of both radiotracers is significantly reduced in fluvastatin-treated and diet-withdrawal rabbits. No uptake of both radiotracers is observed in the control animals. B Quantitative %ID/g Tc-MPI uptake (black bar) and In-AA5 uptake (open bar) of the different study groups is shown. Uptake of both radiotracers is significantly reduced in statin-treated and diet-withdrawal animals compared to the animals on uninterrupted HC diet. C A significant correlation of Tc-MPI and In-AA5 uptake in different groups is observed