Figure 1.

The −log₁₀ of raw P-values obtained through the three proposed strategies in an example randomly selected from the power simulation studies and its LD structure. VSW, BLK and SGL denote association-mapping strategy using variable-sized sliding windows, haplotype blocks, and single SNP loci, respectively. Four hundred cases and an equal number of controls were simulated, with medium recombination rate (10⁻⁸ per site per generation). The x axis shows the simulated loci and the 4-point star in the middle of x axis indicates the location of the putative locus with relative risk of two. The dashed line on top, covering SNP 7 to SNP 13, indicates the best window with which the smallest P-value for VSW was achieved. LD block structure is shown in the bottom frame. The color from white to black represents the increasing strength of LD.