(A–C) Intramolecular and intermolecular contacts change as a result of mutations at positions 66Vβ and 80Vβ, as shown from two orientations for the Vβ-SEC3 complex structures that contain (A) both wild-type residues K66Vβ and E80Vβ, (B) the mutation K66E and the wild-type E80Vβ, or (C) both mutated residues E66Vβ and V80Vβ. Hydrogen bonds are shown as black, dotted lines; van der Waals interactions are shown by black, dashed lines.