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Superpositions of two nucleotide doublets of differing similarities. (a) Two similar stacked doublets (RMSD=0.89 Å). (b) R-Y and Y-R Watson-Crick base-pairs (RMSD=1.75 Å). (c) Watson-Crick base-pair (blue) and a non-canonical base-pair (RMSD=2.93 Å).