Skip to main content
. Author manuscript; available in PMC: 2010 Mar 3.
Published in final edited form as: Neuroscience. 2008 Dec 24;159(1):283–295. doi: 10.1016/j.neuroscience.2008.12.018

Figure 1.

Figure 1

Prolonged CX614 treatment down-regulates AMPAR subunit mRNA levels. A) Film autoradiograms show isotopic in situ hybridization labeling of GluR1-3 mRNAs in hippocampal explants fixed without treatment (Control) or after 24 h of 50 μM CX614 treatment: As shown, CX614 decreased of all three transcript levels in the neuronal layers including stratum (str.) granulosum (sg) and CA1 str. pyramidale (CA1). B–D) Bar graphs show quantification of hybridization densities presented as percent control values for GluR1 (B), GluR2 (C) and GluR3 (D) mRNAs in str. granulosum and CA1 str. pyramidale for groups of slices fixed without treatment (con) or after 3 to 48 h of 50 μM CX614 exposure (n ≥ 7 to 50 slices/group; bars show group means ± S.E.M; *p < 0.05; **p < 0.01; ***p < 0.001 compared to control, SNK).