Table 4.
Genes whose expression was increased the greatest in plerixafor-mobilized CD34+ cells compared with G-CSF–mobilized CD34+ cells
| Gene | Fold increase* | P | |
|---|---|---|---|
| ICSBP1 | Interferon consensus sequence binding protein 1 | 6.14 | 9.20 × 10−6 |
| BLNK | B-cell linker | 5.99 | 1.30 × 10−6 |
| CXCR4 | CXC chemokine receptor 4 | 5.17 | 1.17 × 10−5 |
| CXCR4 | CXC chemokine receptor 4 | 5.07 | 4.80 × 10−6 |
| CDK5R1 | Cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 4.62 | 3.80 × 10−6 |
| TP53I11 | Tumor protein p53 inducible protein 11 | 4.35 | 8.40 × 10−6 |
| SMAD7 | Homologue of Mothers Against Decapentaplegic (MAD) = negative regulator of TGF-beta signaling | 4.19 | 8.90 × 10−6 |
| FLT3 | Fms-related tyrosine kinase 3 | 3.44 | 2.05 × 10−6 |
| CXCR4 | CXC chemokine receptor 4 | 3.32 | 2.49 × 10−4 |
| LDB2 | LIM domain binding 2 | 3.23 | 3.24 × 10−4 |
| COG1 | Component of oligomeric golgi complex 1 | 3.12 | 3.15 × 10−5 |
| DCN | Decorin | 3.04 | 5.96 × 10−5 |
| IL23A | Enhancer of polycomb homolog 1 (Drosophila) | 2.95 | 3.58 × 10−3 |
| AGTRL1 | Angiotensin II receptor-like 1 | 2.92 | 4.68 × 10−4 |
| SPIB | Spi-B transcription factor | 2.91 | 5.17 × 10−4 |
| EBI2 | Epstein-Barr virus–induced gene 2 (lymphocyte-specific G protein–coupled receptor) | 2.90 | 1.81 × 10−4 |
| IL7R | Interleukin-7 receptor | 2.86 | 1.81 × 10−4 |
| TRAT1 | T-cell receptor–associated transmembrane adaptor 1 | 2.83 | .014 |
| GAP43 | Growth associated protein 43 | 2.82 | 7.42 × 10−4 |
| CD79A | CD79A, BCR alpha chain = mb-1 | 2.95 | 3.58 × 10−3 |
| TIEG | TGF-beta inducible early protein | 2.75 | 1.84 × 10−4 |
| IL18R1 | Interleukin-18 receptor 1 | 2.73 | 8.62 × 10−3 |
| SMARCD | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.73 | 2.73 × 10−3 |
| BTK | Btk = Bruton agammaglobulinemia tyrosine kinase | 2.72 | 2.67 × 10−3 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 2.67 | .037 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 2.63 | 3.46 × 10−3 |
*
The fold increase for each gene is the average expression of each gene in plerixafor-mobilized CD34+ cells from 3 rhesus macaque divided by the average expression of the same gene in G-CSF–mobilized CD34+ cells from 3 monkeys.