Table 5.

KEGG pathways with the most genes up-regulated and down-regulated in CD34⁺ cells mobilized by plerixafor plus G-CSF compared with those mobilized by plerixafor alone and G-CSF alone

Pathways with genes up-regulated by plerixafor plus G-CSF		Pathways with genes down-regulated by plerixafor plus G-CSF
Pathway	No. of up-regulated genes in pathway	Pathway	No. of down-regulated genes in pathway
Cytokine-cytokine receptor interaction	68	MAPK signaling pathway	51
MAPK signaling pathway	63	Focal adhesion	46
Natural killer cell–mediated cytotoxicity	41	Oxidative phosphorylation	40
Jak-STAT signaling pathway	39	Calcium signaling pathway	37
Focal adhesion	33	Ribosome	36
Leukocyte transendothelial migration	33	Cytokine-cytokine receptor interaction	33
Regulation of actin cytoskeleton	32	Wnt signaling pathway	33
Insulin signaling pathway	29	Tight junction	31
Cell cycle	28	Jak-STAT signaling pathway	29
Gap junction	28	Cell adhesion molecules	28
Calcium signaling pathway	25	Natural killer cell–mediated cytotoxicity	28
Fc epsilon RI signaling pathway	25	Insulin signaling pathway	27
Oxidative phosphorylation	25	Axon guidance	26
Ubiquitin mediated proteolysis	25	ErbB signaling pathway	25
T-cell receptor signaling pathway	24	Small cell lung cancer	25
B-cell receptor signaling pathway	22	Antigen processing and presentation	23
Cell adhesion molecules	22	Leukocyte transendothelial migration	23
Toll-like receptor signaling pathway	22	Gap junction	22
Wnt signaling pathway	22	Hematopoietic cell lineage	22
GnRH signaling pathway	21	Long-term depression	22
Melanogenesis	21	Regulation of actin cytoskeleton	22
Tight junction	21	VEGF signaling pathway	22
Apoptosis	20	Colorectal cancer	21
Hematopoietic cell lineage	20	T-cell receptor signaling pathway	21
Pathogenic Escherichia coli infection—EHEC	20	Ubiquitin mediated proteolysis	21