Table 6.
Genes whose expression was increased the greatest in plerixafor plus G-CSF–mobilized CD34+ cells compared with those mobilized by plerixafor alone and G-CSF alone
| Gene | Description | Fold increase* | Parametric P |
|---|---|---|---|
| MGC27165 | Immunoglobulin alpha (1 or 2) heavy chain constant region | 9.04 | 2.45 × 10−4 |
| BTK | btk = Bruton agammaglobulinemia tyrosine kinase | 5.13 | < 1 × 10−7 |
| PILRB | Similar to hCG2024106 | 5.07 | 2.70 × 10−6 |
| IGHG3 | Immunoglobulin gamma 3 heavy chain constant region | 5.04 | 3.26 × 10−3 |
| IL1R2 | Interleukin 1 receptor, type II | 4.82 | 2.69 × 10−4 |
| GNA14 | G alpha 14 = guanine nucleotide binding protein alpha 14 | 4.72 | <1 × 10−7 |
| ULK2 | Unc-51-like kinase 2 (C. elegans) | 4.26 | 1.27 × 10−3 |
| BAI3 | Brain-specific angiogenesis inhibitor 3 | 4.16 | 3.92 × 10−4 |
| IL8 | Interleukin 8 | 3.98 | 2.28 × 10−4 |
| HRASLS3 | HRAS-like suppressor 3 | 3.68 | 2.24 × 10−4 |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 3.67 | 1.61 × 10−4 |
| PPM1A | Protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform | 3.61 | 1.30 × 10−6 |
| CYP3A7 | Cytochrome P450, family 3, subfamily A, polypeptide 7 | 3.59 | 1.45 × 10−5 |
| CCR1 | Chemokine (C-C motif) receptor 1 | 3.58 | 1.31 × 10−3 |
| CX3CR1 | Chemokine (C-X3-C motif) receptor 1 | 3.58 | 1.39 × 10−3 |
| UBE2K | Ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) | 3.43 | 3.00 × 10−7 |
| RPL3L | Ribosomal protein L3-like | 3.42 | 3.00 × 10−7 |
| HOXA9 | Homeobox A9 | 3.40 | 2.10 × 10−4 |
| TMSB10 | Thymosin beta 10 | 3.38 | 1.34 × 10−3 |
| ZNF644 | Zinc finger protein 644 | 3.34 | 1.74 × 10−3 |
| HIRA | HIR histone cell-cycle regulation defective homolog A (S cerevisiae) | 3.31 | 2.33 × 10−5 |
| LLT1 | Lectin-like NK-cell receptor | 3.30 | 4.62 × 10−5 |
| PRDM15 | PR domain containing 15 | 3.23 | 2.82 × 10−4 |
| TIMP3 | Tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 3.19 | 2.26 × 10−4 |
| ACACA | Acetyl-coenzyme A carboxylase alpha | 3.14 | 2.70 × 10−6 |
| GZMA | Granzyme A (granzyme 1, cytotoxic T-lymphocyte–associated serine esterase 3) | 3.12 | 1.19 × 10−3 |
| ICOS | Inducible T-cell co-stimulator | 3.09 | 2.63 × 10−4 |
| CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 3.05 | 3.64 × 10−5 |
| LYN | Lyn = tyrosine kinase | 3.02 | 8.78 × 10−5 |
| GPA33 | Glycoprotein A33 (transmembrane) | 3.02 | 1.74 × 10−4 |
*
The fold increase for each gene is the average expression in the plerixafor plus G-CSF–mobilized CD34+ cells from 3 rhesus divided by the average expression of the same gene in the CD34+ cells mobilized by plerixafor from 3 monkeys and CD34+ cells mobilized by G-CSF from 3 monkeys.