Table 7.
Genes whose expression was decreased the greatest in plerixafor plus G-CSF–mobilized CD34+ cells compared with those mobilized by plerixafor alone and G-CSF alone
| Gene symbol | Description | Fold decrease* | Parametric P |
|---|---|---|---|
| CTSS | Cathepsin S | 13.95 | < 1 × 10−7 |
| C9orf3 | Chromosome 9 open reading frame 3 | 7.64 | 2.16 × 10−4 |
| NTRK2 | Neurotrophic tyrosine kinase, receptor, type 2 | 5.82 | < 1 × 10−7 |
| NMT1 | N-myristoyltransferase 1 | 5.64 | 2.00 × 10−7 |
| SCN1B | Sodium channel, voltage-gated, type I, beta | 5.34 | < 1 × 10−7 |
| IL16 | Interleukin 16 (lymphocyte chemoattractant factor) | 4.98 | 1.20 × 10−6 |
| CYP27B1 | Cytochrome P450, family 27, subfamily B, polypeptide 1 | 4.56 | 2.35 × 10−4 |
| KNS2 | kinesin 2 (60-70 kDa) | 4.45 | 1.18 × 10−4 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 4.373 | 6.81 × 10−4 |
| CCL25 | TECK chemokine (CCL25) | 4.27 | 8.89 × 10−5 |
| PFDN6 | Prefoldin subunit 6 | 4.26 | 2.53 × 10−3 |
| EIF5A | Eukaryotic translation initiation factor 5A | 4.24 | 6.40 × 10−5 |
| TYMS | Thymidylate synthetase | 4.23 | 2.20 × 10−6 |
| OCLN | Occludin = tight junction protein | 4.21 | 2.35 × 10−4 |
| NAT2 | N-acetyltransferase 2 (arylamine N-acetyltransferase) | 4.09 | 8.14 × 10−4 |
| RPL23 | Ribosomal protein L23 | 4.04 | 6.20 × 10−6 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | 4.01 | 1.20 × 10−6 |
| MVD | Mevalonate (diphospho) decarboxylase | 3.84 | 2.33 × 10−5 |
| BMP2 | Bone morphogenetic protein 2 | 3.79 | 3.03 × 10−4 |
| UXT | Ubiquitously expressed transcript | 3.78 | 2.80 × 10−6 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 3.67 | 4.00 × 10−6 |
| KCNA5 | Potassium voltage-gated channel, shaker-related subfamily, member 5 | 3.67 | 1.80 × 10−3 |
| RPS27A | Ribosomal protein S27a = fused to ubiquitin | 3.60 | 1.00 × 10−5 |
| ECH1 | Enoyl coenzyme A hydratase 1, peroxisomal | 3.52 | 2.10 × 10−6 |
| FPR1 | Formyl peptide receptor 1 | 3.41 | 8.60 × 10−6 |
| STAP2 | Signal transducing adaptor family member 2 | 3.36 | 3.15 × 10−4 |
| ZNF525 | Zinc finger protein 525 | 3.27 | 8.30 × 10−5 |
| LAMC3 | Laminin, gamma 3 | 3.23 | 1.03 × 10−3 |
| DES | Desmin | 3.18 | 1.78 × 10−5 |
| RPS15 | Ribosomal protein S15 | 3.17 | 2.80 × 10−6 |
*
The fold decrease for each gene is the average expression in the plerixafor plus G-CSF–mobilized CD34+ cells from 3 rhesus divided by the average expression of the same gene in the CD34+ cells mobilized by plerixafor from 3 monkeys and CD34+ cells mobilized by G-CSF from 3 monkeys.