Table 3.

Variables associated with disseminated versus localized cryptococcosis

Variable	Odds ratio	95% CI	P-value
Univariable analysis
Age	0.99	0.97 – 1.03	0.98
Type of transplant
Liver	1.19	0.76 – 4.84	0.17
Heart	0.81	0.20 – 3.18	0.75
Kidney	1.58	0.65 – 3.81	0.31
Lung	0.19	0.04 – 1.01	0.05
Multiorgan	0.47	0.12 – 1.88	0.29
Renal failure at baseline	1.77	0.72 – 4.35	0.21
Cytomegalovirus infection	0.68	0.29 – 1.58	0.36
Rejection	1.04	0.45 – 2.39	0.93
Time from onset to diagnosis	0.99	0.99 – 1.00	0.35
Months post-transplant to diagnosis	1.10	0.48 – 2.52	0.81
Onset < 1 year post-transplant	1.17	0.51 – 2.66	0.71
Receipt of prednisone	4.32	0.79 – 1.13	0.09
Prednisone, dose	1.03	0.97 – 1.10	0.34
Receipt of a calcineurin inhibitor agent*	0.35	0.09 – 1.32	0.12
Receipt of tacrolimus**	0.34	0.08 – 1.31	0.12
Receipt of cyclosporine A†	0.37	0.079 – 1.76	0.21
Multivariable analysis
Receipt of a calcineurin-inhibitor agent	0.37	0.09 – 1.52	0.17
Receipt of prednisone	1.03	0.96 – 1.10	0.34
Type of Transplant††
Liver	6.65	1.01 – 43.64	0.048
Heart	3.21	0.38 – 26.75	0.28
Kidney	4.07	0.69 – 23.88	0.11
Multiorgan	1.46	0.15 – 13.46	0.73

^*Includes tacrolimus or cyclosporine. Comparison is made with the receipt of a non-calcineurin-inhibitor based regimen (azathioprine or mycophenolate mofetil).

^**Compared to non-tacrolimus regimen.

^†Compared to non-cyclosporine A regimen.

^††Comparison is made with lung transplant recipients as reference.