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. 2002 Jan 7;86(1):143–150. doi: 10.1038/sj.bjc.6600025

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Copyright © 2002 The Cancer Research Campaign

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Induction of JNK1 activation by vinflunine in P388 cells. P388 cells were treated with 0.025 to 0.5 μM vinflunine for 6 h. JNK1 activity was determined in cell lysates by immunocomplex assay, as described in Materials and methods. Results, from two independent experiments, are expressed as average increase of JNK1 activity relative to the controls±s.e.m. Statistical evaluation using the Student t-test showed that the values for 0.25 and 0.5 μM were significant, with respective P values of 0.015 and <0.001.