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Fibrotic ECM components around the INTACS channels. Note significant accumulation of α1/α2 type IV collagen, tenascin-C, fibrillin-1, and type XIV collagen around INTACS channels in both cases. None of these components can be detected in normal corneal stroma.21 Samples in the top row had a remnant of INTACS (INT). INTACS channels are marked by asterisks; KC-1, case 1 with keratoconus. Bar = 60 μm.
