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Proteinase expression in stromal cells around the INTACS channel. Cathepsin F appears in both shown cases (arrows, top row). Staining for cathepsins B and L was largely negative (data not shown). Occasional cells around INTACS area are positive for MMP-3 (arrows, bottom left) in case 1 with keratoconus (KC-1). At the same time, no MMP-9 expression is observed (bottom right). INTACS channel is marked by an asterisk; arrowhead, Descemet membrane (DM). Bar = 60 μm.
