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. Author manuscript; available in PMC: 2010 Apr 9.
Published in final edited form as: J Med Chem. 2009 Apr 9;52(7):1864–1872. doi: 10.1021/jm801343r

Scheme 1.

Scheme 1

Synthetic strategy for the compounds 8–47a.

a Reagents and conditions:(i) CH3COCH2CO2C2H5, AcOH, 3.5 h, reflux, 55%.; (ii) POCI3, 45 min., reflux, 58%.; (iii) Ar-NH2, EtOH, 2–30 h, room temp., 80–87%.