Figure 10.

Calculated structures of tolaasin I (A) MOLMOL stereoview of the best-fit superposition of the 20 lowest energy rSA/rEMconformations of tolaasin. Backbone atoms of residues 2–14 were used for the best fit. (B) Stickgolf-club” like tolaasin I conformation. Dotted lines indicate hydrogen bondsalong the left-handed α-helix. The helical axis inside the helix is also represented. The shaded area simulates the ellipsoid that covers most of the backbone atoms of the lactone ring, and its largest axisis also shown.