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. 2002 May 3;86(10):1604–1614. doi: 10.1038/sj.bjc.6600296

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Copyright © 2002 Cancer Research UK

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Contraction of a host arteriole and a tumour-feeding arteriole caused by 10 mg kg⁻¹ AC7700. (A) before AC7700 administration; (B) 5 min later; (C) 30 min later; (D) 3 h later. Tumour blood flow completely stopped 30 min after i.v. administration of AC7700. Note that an arteriole (white arrow) underwent marked contraction in response to AC7700, and a feeding arteriole (asterisk) into a tumour disappeared from view. Original magnification, ×20. Bar, 250 μm.