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. 2002 May 3;86(10):1592–1596. doi: 10.1038/sj.bjc.6600269

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Copyright © 2002 Cancer Research UK

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Transrepression. Saos-2 cells were transfected, with pC53-SN3 and pSV40-βgal. Cells were washed after 16 h and lysed after a further 24 h. The results show that the 7 base pair insertion is similar to 344P (P=0.33), in that it cannot repress the SV40 promoter, whereas wild-type p53 can.