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. 2002 May 3;86(10):1639–1644. doi: 10.1038/sj.bjc.6600270

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Copyright © 2002 Cancer Research UK

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Diffusion coefficient D of IgG in BAHAN rhabdomyosarcoma growing as tumours (closed symbols) or as multicellular spheroids (open symbols) relative to D₀ in solution. Clones A, B, and C are represented by (•/○), (▪/□), and (▴/▵), respectively. D/D₀ is plotted as a function of collagen (i), s-GAG (ii), and hyaluronan (iii). s-GAG and hyaluronan are expressed as equivalent mass to uronic acid. Each value of D represents the mean and standard error of 4–7 tumours or spheroids with 5–12 FRAP measurements per tumour or spheroid.