Table 1.
Characteristics of Female Survivors of CNS Tumors and Siblings
| Characteristic | Survivors: Early Menarche (n=235) | Siblings: Early Menarche (n=1129) | Survivors: Late Menarche (n=235) | Siblings: Late Menarche (n=1051) |
|---|---|---|---|---|
| Age at cancer diagnosis, years | ||||
| >2 | 25 (10.8) | 14 (6.0) | ||
| 2-4 | 75 (31.9) | 41 (17.4) | ||
| 5-9 | 135 (51.4) | 103 (43.8) | ||
| >10 | 0 | 77 (32.8) | ||
| Histological Subtype | ||||
| Glioma | 152 (64.7) | 147 (62.6) | ||
| Low Grade Glioma | 26 | 20 | ||
| High Grade Glioma | 37 | 30 | ||
| Astrocytoma NOS | 89 | 97 | ||
| Medulloblastoma/PNET | 52 (22.1) | 65 (27.7) | ||
| Other | 31 (13.2) | 23 (9.8) | ||
| Ethnicity | ||||
| Caucasian, non Hispanic | 206 (87.7) | 993 (88.0) | 207 (88.1) | 924 (87.9) |
| Black, non-Hispanic | 10 (4.3) | 27 (2.4) | 9 (3.8) | 25 (2.4) |
| Hispanic/Latino | 8 (3.4) | 39 (3.5) | 7 (3.0) | 37 (3.5) |
| Asian/Native American/Pac. Islander | 1 (0.4) | 12 (1.1) | 1 (0.4) | 12 (1.1) |
| Other | 10 (4.3) | 18 (1.6) | 11 (4.7) | 11 (4.7) |
| Unknown | 0 | 40 (3.5) | 0 | 35 (3.3) |
| Treatment Exposure, % | ||||
| Surgery only | 66 (28.1) | 61 (26.0) | ||
| Surgery + Brain RT | 66 (28.1) | 67 (26.5) | ||
| Surgery + Brain RT + spine RT | 29 (12.3) | 35 (14.9) | ||
| Surgery +Brain RT + chemo | 21 (8.9) | 15 (6.4) | ||
| All 4 treatment modalities | 21 (8.9) | 25 (10.6) | ||
| Chemo only | 2 (0.9) | 0 | ||
| Unknown | 30 (12.8) | 32 (13.6) | ||
| Dose to H-P Axis a | ||||
| None | 82 (41.8) | 72 (38.5) | ||
| 1 - 20 Gy | 0 | 0 | ||
| 20.01 - 30 Gy | 3 (1.5) | 4 (2.1) | ||
| 30.01 - 40 Gy | 23 (11.7) | 24 (12.8) | ||
| 40.01 - 50 Gy | 47 (24.0) | 30 (16.0) | ||
| >50 Gy | 41 (20.1) | 57 (30.5) | ||
| Timing of Menarche | ||||
| Early (<10 years) | 28 (11.9) | 10 (1.0) | ||
| Late (>16 years) | 25 (10.6) | 20 (1.9) |
a
Percentages exclude survivors (n = 39) and siblings (n = 48) in whom dose was unknown
RT = Radiation Therapy, H-P Axis = Hypothalamic-Pituitary Axis, Gy = Grey