Table 2.

Risk of Abnormal Timing of Menarche in Survivors of CNS Tumors : Multivariate Model

		Odds Ratio	95% CI
Early Menarche
	RT Dose H-P Axis †
	1 - 40 Gy	2.58	0.48-11.96
	40.01 - 50 Gy	1.86	0.48-7.17
	>50 Gy	3.69 *	1.07-13.74
	No RT (referent)	1.00	-
	Age at Diagnosis
	≤4 years	3.96 *	1.48-11.92
	5-9 years (referent)	1.00	-
Late Menarche
	RT to H-P Axis +/- Spine RT
	H-P axis ≤ 50 Gy, no spine RT	1.84	0.21-16.07
	H-P axis ≤ 50 Gy, plus spine RT	4.73	0.86-36.0
	H-P axis > 50 Gy, no spine RT	6.90 *	1.46-49.57
	H-P axis >50 Gy, plus spine RT	12.40 *	2.66-89.64
	No RT (referent)	1.00	-
	Age at Diagnosis
	10-20 years	2.39	0.90-6.45
	0-9 years (referent)	1.00

^*= value is statistically significant (p<.05)

RT = Radiation Therapy, H-P Axis = Hypothalamic-Pituitary Axis, Gy = Grey, CI = Confidence Interval