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. Author manuscript; available in PMC: 2010 Apr 15.
Published in final edited form as: Biol Psychiatry. 2009 Feb 28;65(10):874–880. doi: 10.1016/j.biopsych.2009.01.024

Figure 2.

Figure 2

The CUS-induced changes in gene expression in the nucleus accumbens (NAc) are blunted in OVX female subjects. Microarray analysis was performed on the NAc of intact and OVX female mice in control and CUS conditions 24 hours after the last stress (n = 3). (A) Heatmap of 619 genes significantly regulated by stress in intact mice and how these genes are regulated by stress in OVX mice. Stressed-induced gene expression is blunted or reversed by OVX. (B) Heatmap of 170 genes significantly regulated by stress in OVX mice and how these genes are regulated by stress in intact female mice. Stress-induced changes in gene expression are strikingly reversed in OVX animals. See Supplement 2 for complete gene lists. down-reg, downregulated; up-reg, upregulated; other abbreviations as in Figure 1.