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. Author manuscript; available in PMC: 2010 Apr 15.
Published in final edited form as: Biol Psychiatry. 2009 Feb 28;65(10):874–880. doi: 10.1016/j.biopsych.2009.01.024

Figure 3.

Figure 3

The OVX upregulates nuclear factor κ B (NFκB) subunit expression and transcriptional activity in the NAc. (A) The NFκB activity was greatly increased in the NAc of OVX NFκB-LacZ reporter mice (n =4). (B–D) Likewise we validated OVX regulation of NFκB subunits, as seen on gene expression arrays, and find that these changes are long-lived. Real time quantitative polymerase chain reaction data of NFκB genes shows increased expression of the NFκB subunits p105 (B, C) and p65 (D, E) at 3 and 6 weeks after OVX (n = 6 –7). *indicates statistically significant differences at p < .05. Abbreviations as in Figure 1.