Table 1.

Antimalarial Efficacy and Toxicity Evaluation^a

Test Compounds	In Vitro W2 Strain	In Vivo P. berghei (ED50, mg/kg)	MCD (mg/kg)	MTD (mg/kg)	TIb
7	0.56	1.6	8.4	144	17
8	0.12	0.44	3.1	345	111
9	0.14	0.49	2.9	310	107
10	0.31	1.2	6.6	338	51
11	0.34	1.3	5.9	439	74
12	0.29	1.0	7.1	399	56
13	0.26	1.1	6.8	425	63
14	0.40	1.7	8.9	379	43
15	0.23	0.74	4.7	335	71
16	0.28	1.5	7.9	440	56
17	2.9	8.7	39	429	11
18	3.4	10	42	504	12
19	0.14	0.14	0.77	102	132
20	0.19	0.12	0.69	88	128
21	0.62	1.7	5.6	55	10
22	0.57	1.5	4.9	51	10
Febrifugine	0.76	2.3	12	35	3
Chloroquine	224	4.5	40.0	240	6

^aAntimalarial activities were determined after i.p. administration of the compounds once daily for 4 days to infected mice.

^bTherapeutic indices were calculated as MTD divided by MCD.