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. Author manuscript; available in PMC: 2010 Feb 20.
Published in final edited form as: Nature. 2009 Aug 20;460(7258):1016–1020. doi: 10.1038/nature08236

Figure 3. Axonal morphology is normal, but multiple ribbons accumulate at fewer synapses in TeNT-expressing ON BCs.

Figure 3

a-f, Axon arbors of representative type 7 (a) and type 6 (c) ON cone BCs, and rod BCs (e) labeled in an mGluR6-tdTomato mouse in wildtype (left) or mGluR6-YFP/TeNT (right) background at P21. TdTomato signal was used to mask arbors of single BCs. Summary data (mean ± s.e.m.) comparing stratification (b), lateral territories (d), and axonal density (f) between wildtype and mGluR6-YFP/TeNT background. g, Synapses on BC terminals labeled with anti-CtBP2. TdTomato signal shown in mGluR6-YFP/TeNT background (left) was used as a mask to isolate ribbon synapses of an individual axonal arbor (right). h, Mean (± s.e.m.) density of synapses for the different BC types. * indicates p < 0.01. i, Electron micrographs of ON BC ribbon synapses of in wildtype (right) and mGluR6-YFP/TeNT (left) littermates at P21. j, Histogram of the number of ribbons per synapse for wildtype (white, n = 25) and mGluR6-YFP/TeNT (red, n = 25) mice.