Table 2.

Effects of treatment at six weeks. Analyses are on an intention to treat basis unless indicated otherwise. Values are least square means unless indicated otherwise

	Treatment		Difference of least square means (95% CI)*		P value†
	Hypericum (n=157)	Imipramine (n=167)
Primary variable
Hamilton depression rating scale:‡
Change from baseline score	12.00	12.75	−0.75 (−1.90 to 0.40)		0.20
Change from baseline score (analysis of data from patients who complied with protocol)	11.53	11.21	0.32 (−0.72 to 1.36)		0.55
Secondary variables
Hamilton depression scale:
Score on anxiety-somatisation subscale	3.79	4.26	−0.48 (−0.91 to −0.04)		0.03
Score on depression subscale	4.33	4.57	−0.24 (−0.74 to 0.26)		0.35
Score on clinical global impression scale‡	2.22	2.42	−0.20 (−0.42 to 0.02)		0.08
Score on patient's global impression scale‡	2.44	2.60	−0.16 (−0.40 to 0.09)		0.20
Score of patient's assessment of tolerability	1.67	2.35	−0.68 (−0.88 to −0.49)		0.00

^*Least square means are derived from the general linear model (analysis of covariance). The means are adjusted (end points reflect changes corrected for baseline values). 

^†P values are exploratory; they are derived from the statistical analyses conducted to construct confidence intervals. 

^‡Lower scores indicate greater improvement.