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. Author manuscript; available in PMC: 2009 Sep 18.
Published in final edited form as: Science. 2008 May 16;320(5878):946–949. doi: 10.1126/science.1155244

Fig. 1.

Fig. 1

Celsr3 expression is required intrinsically in neurons of origin of the AC. (A) Schematic representation of the AC, composed of a rostral component (R) that contains commissural axons connecting olfactory nuclei and a caudal component (C) made of axons that connect temporal lobes. OB indicates olfactory bulb. (B and C) Montages of coronal sections at the level of the AC in newborn animals. The control phenotype is shown on the left side, and the right side shows Celsr3| Foxg1 (B) and Celsr3|Emx1 (C) mice. Note the rudiment of AC in Celsr3| Emx1 mice (arrow in C). (D to F) Horizontal sections at birth day (P0) after DiI injection in control (D), Celsr3| Foxg1 (E), and Celsr3|Emx1 mice (F). Arrows in (C) and (F) point to rudiments of AC that never cross the midline.