Table 3.
Menopause classification | |||||||
---|---|---|---|---|---|---|---|
Pre or peri-menopause | Post No HT | Post With HT | Surgical No E2/HT† | Surgical With E2/HT† | HT use | Model P | |
LSM ± SE | LSM ± SE | LSM ± SE | LSM ± SE | LSM ± SE | LSM ± SE | ||
N | 144 (33%) | 164 (37%) | 18 (4%) | 47 (11%) | 37 (8%) | 29 (7%) | |
Age (yr) | 46 ± 0.3 | 53 ± 0.3 | 53 ± 0.9 | 50 ± 0.6 | 51 ± 0.6 | 46 ± 0.7 | <.001 |
BMI (kg/m2) | 29 ± 0.5 | 29 ± 0.5 | 28 ± 1.4 | 30 ± 1.0 | 28 ± 1.1 | 26 ± 1.1 | 0.13 |
Physical Functioning | |||||||
Grip strength, dominant hand (kg) | 26.2 ± 0.5 | 23.8 ± 0.4 | 25.4 ± 1.2 | 24.2 ± 0.8 | 23.7 ± 0.9 | 26.9 ± 1.0 | 0.001 |
Leg strength (Nm) | 80 ± 2.7 | 73 ± 2.2 | 71 ± 6.5 | 69 ± 3.8 | 75 ± 5.0 | 72 ± 5.1 | 0.22 |
Forward reach (cm) | 35 ± 0.5 | 35 ± 0.5 | 34 ± 1.3 | 34 ± 0.8 | 35 ± 1.0 | 35 ± 1.1 | 0.82 |
2-lb lift (sec) | 1.6 ± 0.03 | 1.8 ± 0.3 | 1.7 ± 0.10 | 2.0 ± 0.07 | 2.0 ± 0.09 | 1.7 ± 0.08 | <0.001 |
Sit-to-stand (sec) | 1.0 ± 0.03 | 1.0 ± 0.03 | 0.9 ± 0.07 | 1.2 ± 0.06 | 1.2 ± 0.07 | 1.0 ± 0.06 | <0.001 |
40-foot timed walk (sec) | 8.0 ± 0.1 | 8.3 ± 0.1 | 7.8 ± 0.3 | 8.5 ± 0.2 | 9.1 ± 0.2 | 7.8 ± 0.2 | <0.001 |
Timed stair climb (sec) | 16.3 ± 0.3 | 17.6 ± 0.3 | 16.0 ± 0.8 | 18.4 ± 0.6 | 19.6 ± 0.7 | 16.1 ± 0.6 | <0.001 |
Velocity (cm/s) | 170 ± 2.5 | 164 ± 2.2 | 175 ± 6.7 | 162 ± 4.0 | 149 ± 4.9 | 178 ± 5.8 | <0.001 |
SF-36 physical functioning score | 91 ± 1.5 | 84 ± 1.4 | 92 ± 4.2 | 80 ± 2.6 | 77 ± 3.0 | 91 ± 3.3 | <0.001 |
Serum hormones | |||||||
Follicle-stimulating hormone (mIU/mL) | 10.4 ± 0.7 | 66.9 ± 4.0 | 37.8 ± 6.2 | 52.5 ± 5.7 | 37.0 ± 4.8 | 13.9 ± 2.0 | <0.001 |
Estradiol (pg/mL) | 80.9 ± 6.0 | 19.1 ± 1.3 | 32.4 ± 6.6 | 29.2 ± 3.6 | 41.4 ± 6.1 | 38.8 ± 6.2 | <0.001 |
N (%) | |||||||
Health status | |||||||
Excellent | 25 (17%) | 34 (21%) | 4 (22%) | 1 (2%) | 3 (8%) | 9 (31%) | 0.001‡ |
Very good | 61 (42%) | 54 (33%) | 6 (33%) | 13 (28%) | 8 (22%) | 11 (38%) | |
Good | 50 (35%) | 53 (32%) | 7 (39%) | 22 (47%) | 19 (51%) | 5 (17%) | |
Fair or poor | 8 (5%) | 23 (14%) | 1 (5%) | 11 (23%) | 7 (19%) | 4 (14%) |
Data censored for N=24 participants in 2005/06, due to unverified surgery.
E2/HT represents ovarian conservation and/or HT use.
Chi-square p-value.