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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Cell Motil Cytoskeleton. 2009 Aug;66(8):546–555. doi: 10.1002/cm.20364

Fig 3.

Fig 3

Model for dynein localization and function. Dynein and its activator, dynactin, are targeted to microtubule plus ends by a complex of kinesin and CLIP-170. Retention of dynein-dynactin at the plus end requires LIS1 and NudEl, and may also involve CLIP-170. By associating processively with the plus end, microtubule growth delivers dynein-dynactin to the cortical receptor, Num1. Interaction with Num1 facilitates the docking of dynein-dynactin to the cell cortex. Activation of motor activity causes dynein to then walk toward the microtubule minus end, which pulls the attached spindle pole and proximal edge of the nuclear envelope toward the anchored motor.