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. 2009 Jul 15;102(3):1801–1810. doi: 10.1152/jn.00354.2009

FIG. 2.

FIG. 2.

The somatostatin receptor 2 (sst2) agonist, MK-678, mimics the effect of SS14. A: L-VGCC current densities were larger when photoreceptors were recorded during the subjective night (CT 16–19; ▪) than during the subjective day (CT 4–7; •). B and C: application of MK-678 (100 nM) for 2 h prior to recordings had no effect during the subjective day (CT 4–7; ○; B) but caused a significant decrease in L-VGCC current density during the subjective night (CT 16–19; □; C). D: MK-678 significantly inhibited the maximum L-VGCC current density (Imax) during the subjective night but not the subjective day. Control (Con) CT 4–7: 3.9 ± 0.7 pA/pF, n = 11; control CT 16–19: 6.4 ± 0.8 pA/pF, n = 13; MK-678 CT 4–7: 5.4 ± 1.4 pA/pF, n = 13; MK-678 CT 16–19: 2.5 ± 1.0 pA/pF, n = 8. *P < 0.05.