Table 6.

Parameter estimations and likelihood ratio tests for the branch-site models

	df	Parameter estimatesa	lnLb	2⊿c	P value	Positive selected sites
FoxO1
MA Vs M1a (test 1)	2	p0 = 0.70592 p1 = 0.18493 (p2 = 0.10915) w0 = 0.07205 (w1 = 1.00000) w2 = 1.00000	-22667.231	81.89419	P < 0.01	213S** 216S* 219S* 252M* 276V** 285P* 296L** 306A** 340F* 360E*
FoxO3
MA Vs M1a (test 1)	2	p0 = 0.77299 p1 = 0.10453 (p2 = 0.12248) w0 = 0.06958 (w1 = 1.00000) w2 = 1.00000	-22646.766	122.8257	P < 0.01	5H** 25D* 26F** 33D** 34L**37N** 217A* 231G** 329G*
FoxO4
MA Vs M1a (test 1)	2	p0 = 0.67705 p1 = 0.18055 (p2 = 0.1424) w0 = 0.07468 (w1 = 1.00000) w2 = 1.00000	-22660.108	96.14052	P < 0.01	7V** 173R** 194T** 201I** 202L** 211F**223H* 225P** 242T* 254R** 314S**
FoxO6
MA Vs M1a (test 1)	2	p0 = 0.58516 p1 = 0.13030 (p2 = 0.28454) w0 = 0.06572 (w1 = 1.00000) w2 = 1.05311	-22527.632	361.0936	P < 0.01	42Q** 46K** 155I* 164T** 165N** 173R* 174E** 176E** 178L** 179F** 180C** 188I* 189V** 203L* 207R* 223H** 230I** 231G* 232Y** 233K** 234N** 237Y** 258S** 265N* 269T** 271E** 272N** 273E** 274V** 275H** 276V** 277S** 278Q* 279G** 280L** 281H** 282P** 283S** 286N* 314S** 316V** 320H** 330Y* 366T** 367G** 368T** 369P*

Note: ^aThe number of free parameters;

^bLikelihood of the model;

^c2(l₁-l₀);

* P > 0.95;

** P > 0.99;

The bold amino acid residues were also found to be implicated in the functional divergence (implemented in Diverge 2.0) between FoxO