Representative wheel-running actograms from mice following various light-dark manipulations. (A) BALB/cJ mice re-entrain to a 6-hr advance of the light-dark cycle within 1–2 circadian cycles, whereas C57BL/6J mice require 4–5 days. (B) A single-day 6-hr advance of the light-dark cycle followed by release to constant darkness induces large phase advances in BALB/cJ, but not C57BL/6J mice. (C) Release to constant darkness reveals similar phase angles of entrainment for both strains. (D) Release to constant light has no effect on phase of BALB/cJ rhythms, but yields phase delays in C57BL/6J mice. Shaded areas correspond to lights off. (**, p<.01; ***, p<.001)