Table 1.
Single-locus association results from the ISHDSF grouped by gene.
| P-Value
|
|||||||
|---|---|---|---|---|---|---|---|
| Marker | Position | Alleles (minor) | Gene | Role | Risk allele | Allele- PDT | Geno- PDT |
| rs26195391 | chr6:15728834 | C/G (G) | DTNBP1 | Intron | - | 0.415 | 0.282 |
| rs168767381 | chr6:15735532 | A/G (A) | DTNBP1 | Intron | - | 0.317 | 0.053 |
| rs10113131 | chr6:15741411 | A/G (G) | DTNBP1 | Intron | G | 0.861 | 0.049 |
| rs20059761 | chr6:15758781 | A/G (G) | DTNBP1 | Intron | G | 0.006 | 0.008 |
| rs7607611 | chr6:15759111 | C/T (T) | DTNBP1 | Intron | T | 0.006 | 0.001a |
| rs26195221 | chr6:15761628 | C/A (A) | DTNBP1 | Intron | T | 0.021 | 0.026 |
| rs10183811 | chr6:15765049 | C/T (T) | DTNBP1 | Intron | - | 0.116 | 0.155 |
| rs2072707 | chr22:35643581 | G/T (T) | CSF2RB | Intron | - | 0.217 | 0.496 |
| rs2284031 | chr22:35645580 | C/T (T) | CSF2RB | Intron | - | 0.063 | 0.200 |
| rs17811365 | chr22:35647320 | G/T (G) | CSF2RB | Intron | - | 0.389 | 0.555 |
| Rs909486 | chr22:35648488 | C/T (T) | CSF2RB | Intron | - | 0.059 | 0.096 |
| rs2075936 | chr22:35653251 | A/G (G) | CSF2RB | Intron | - | 0.730 | 0.787 |
| rs11705394 | chr22:35654176 | C/T (C) | CSF2RB | Intron | - | 0.387 | 0.133 |
| rs7285064 | chr22:35654499 | C/T (T) | CSF2RB | S/S | - | 0.277 | 0.031 |
| Rs131840 | chr22:35658294 | C/T (T) | CSF2RB | P/P | - | 0.310 | 0.583 |
| Rs131842 | chr22:35660273 | C/T (C) | CSF2RB | 3' UTR | - | 0.285 | 0.507 |
| rs10302711 | chr5:130660554 | C/G (C) | SPEC2 | Intron | C | 0.024 | 0.095 |
| rs25490121 | chr5:130687657 | A/C (C) | SPEC2 | Intron | C | 0.005 | 0.004 |
| rs47060201 | chr5:130701975 | A/G (A) | SPEC2 | Intron | A | 0.022 | 0.087 |
| rs37562951 | chr5:130720739 | C/G (G) | SPEC2 | Intron | G | 0.001a | 0.001a |
| Rs403961 | chr5:130735943 | C/G (G) | SPEC2 | Intron | G | 0.009 | 0.037 |
| Rs277081 | chr5:130771440 | A/G (G) | G | 0.019 | 0.065 | ||
| rs49965221 | chr5:130789369 | A/G (A) | PDZ-GEF2 | 3' UTR | G | 0.004 | 0.023 |
| rs12916021 | chr5:130794561 | C/T (T) | PDZ-GEF2 | Q/R | - | 0.148 | 0.321 |
| rs7399521 | chr5:130824467 | A/T (T) | PDZ-GEF2 | Intron | T | 0.009 | 0.036 |
| rs2447391 | chr5:130834773 | A/C (C) | PDZ-GEF2 | Intron | C | 0.005 | 0.021 |
| Rs312511 | chr5:130861845 | A/G (G) | PDZ-GEF2 | Intron | G | 0.045 | 0.009 |
| rs68735821 | chr5:130920640 | A/G (A) | PDZ-GEF2 | Intron | G | 0.018 | 0.074 |
| rs14228711 | chr5:130970380 | C/T (T) | PDZ-GEF2 | Intron | T | 0.011 | 0.043 |
| rs1528151 | chr5:131054117 | A/G (A) | KIAA1961 | Intron | A | 0.005 | 0.028 |
| Rs131642361 | chr5:131107707 | C/T (C) | KIAA1961 | Intron | T | 0.019 | 0.072 |
| rs15664271 | chr5:131219571 | A/G (G) | ACSL6 | Intron | G | 0.011 | 0.027 |
| rs13550951 | chr5:131276668 | A/G (G) | ACSL6 | Intron | - | 0.478 | 0.650 |
| rs6674371 | chr5:131303408 | A/G (A) | ACSL6 | Intron | - | 0.065 | 0.242 |
| rs4770861 | chr5:131312509 | C/T (T) | ACSL6 | Intron | - | 0.074 | 0.264 |
| rs6153051 | chr5:131319755 | A/G (G) | ACSL6 | Intron | G | 0.013 | 0.040 |
| rs22405251 | chr5:131343783 | A/G (G) | ACSL6 | Intron | G | 0.009 | 0.003 |
| rs3997141 | chr5:131346687 | C/T (T) | ACSL6 | Intron | T | 0.019 | 0.095 |
| Rs779381 | chr5:131350393 | C/T (C) | ACSL6 | Intron | - | 0.161 | 0.349 |
| rs4409701 | chr5:131364186 | G/T (G) | ACSL6 | Intron | - | 0.263 | 0.626 |
| rs2469991 | chr5:131376070 | A/G (G) | ACSL6 | Intron | G | 0.029 | 0.076 |
| rs39140251 | chr5:131381184 | C/T (T) | ACSL6 | Intron | - | 0.344 | 0.635 |
| rs38467261 | chr5:131386898 | A/G (T) | ACSL6 | Promoter | - | 0.289 | 0.790 |
| rs39164411 | chr5:131397140 | A/G (A) | - | 0.412 | 0.564 | ||
| Rs314001 | chr5:131417406 | C/T (T) | IL3 | Promoter | - | 0.454 | 0.779 |
| Rs314801 | chr5:131424231 | C/T (T) | IL3 | Promoter | T | 0.029 | 0.109 |
| Rs404011 | chr5:131424377 | C/T (T) | IL3 | P/S | T | 0.017 | 0.082 |
| Rs314811 | chr5:131425101 | A/G (A) | IL3 | Intron | - | 0.074 | 0.179 |
| rs20698031 | chr5:131428332 | C/T (C) | IL3 | 3' UTR | T | 0.005 | 0.026 |
| Rs109176701 | chr1:159764500 | C/T (T) | RGS4 | Promoter | - | 0.569 | 0.442 |
| rs9514361 | chr1:159765000 | A/T (T) | RGS4 | Promoter | - | 0.906 | 0.459 |
| rs9514391 | chr1:159765349 | C/T (T) | RGS4 | Promoter | - | 0.871 | 0.315 |
| rs26613191 | chr1:159771435 | A/G (G) | RGS4 | Intron | - | 0.359 | 0.704 |
1
Markers also genotyped in the ICCSS
a
Exceeds the threshold for significance for any single-locus test from either sample