Table 2.
Standardized hazard ratios for mortality associated with a one standard deviation increase in systolic blood pressure, total cholesterol and 2-hour glucose
| Systolic blood pressure | p-value for sex interaction | ||
|---|---|---|---|
| HR* (95% CI), p-value | HR* (95% CI), p-value | ||
| WOMEN | MEN | ||
| All cause mortality | 1.25 (1.13–1.39), <0.001 | 1.18 (1.10–1.27), <0.001 | 0.57 |
| CVD mortality | 1.45 (1.25–1.68), <0.001 | 1.38 (1.26–1.51), <0.001 | 0.97 |
| CHD mortality | 1.09 (0.86–1.38), 0.47 | 1.34 (1.20–1.51), <0.001 | 0.06 |
| Stroke mortality | 2.17 (1.70–2.75), <0.001 | 1.69 (1.37–2.09), <0.001 | 0.18 |
| Cancer mortality | 1.03 (0.84–1.26), 0.80 | 0.98 (0.85–1.14), 0.80 | 0.67 |
| Respiratory mortality | 1.05 (0.77–1.43), 0.77 | 1.02 (0.83–1.26), 0.83 | 0.97 |
| Total Cholesterol | p-value for sex interaction | ||
| HR** (95% CI), p-value | HR** (95% CI), p-value | ||
| WOMEN | MEN | ||
| All cause mortality | 1.22 (1.08–1.37), <0.001 | 0.98 (0.91–1.06), 0.68 | 0.007 |
| CVD mortality | 1.39 (1.16–1.66), 0.001 | 1.09 (0.98–1.21), 0.11 | 0.05 |
| CHD mortality | 1.40 (1.09–1.80), 0.008 | 1.10 (0.96–1.25), 0.17 | 0.14 |
| Stroke mortality | 1.53 (1.11–2.11), 0.01 | 1.15 (0.89–1.49), 0.28 | 0.21 |
| Cancer mortality | 1.10 (0.88–1.37), 0.41 | 0.86 (0.74–0.99), 0.04 | 0.06 |
| Respiratory mortality | 1.20 (0.83–1.73), 0.34 | 0.91 (0.75–1.10), 0.33 | 0.25 |
| 2-hour glucose† | p-value for sex interaction | ||
| HR*** (95% CI), p-value | HR*** (95% CI), p-value | ||
| WOMEN | MEN | ||
| All cause mortality | 1.06 (0.96–1.17), 0.25 | 1.15 (1.07–1.23), <0.001 | 0.17 |
| CVD mortality | 1.10 (0.95–1.27), 0.20 | 1.21 (1.10–1.33), <0.001 | 0.23 |
| CHD mortality | 1.05 (0.85–1.30), 0.66 | 1.25 (1.12–1.40), <0.001 | 0.12 |
| Stroke mortality | 1.25 (0.97–1.61), 0.08 | 1.06 (0.83–1.35), 0.65 | 0.38 |
| Cancer mortality | 1.03 (0.86–1.25), 0.73 | 1.11 (0.97–1.27), 0.13 | 0.94 |
| Respiratory mortality | 1.11 (0.85–1.45), 0.46 | 1.21 (1.00–1.47), 0.05 | 0.55 |
*
Hazard ratio associated with a 1 SD increase in Systolic BP (20.4 mmHg women; 21.4 mmHg men)
**
Hazard ratio associated with a 1 SD increase in cholesterol (1.14 mm/L women; 1.16 mm/L men)
***
Hazard ratio associated with a 1 SD increase in 2-hour glucose (0.68 mm/L women; 0.87 mm/L men)
†
2-hr glucose adjusted for time since glucose load (see statistical methods)