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. Author manuscript; available in PMC: 2009 Nov 21.
Published in final edited form as: N Engl J Med. 2008 Nov 20;359(21):2208–2219. doi: 10.1056/NEJMoa0804742

Figure 1. Distribution of Genotype Score and Cumulative Incidence of Type 2 Diabetes According to Genotype Score among Participants in the Framingham Offspring Study.

Figure 1

The panels were drawn on the basis of 2434 participants with complete genotypic data. (Data on 2377 participants with complete genotypic and phenotypic data were included in the remainder of the analysis reported in this article.) Panel A shows the distribution of participants in the Framingham Offspring Study according to genotype score, stratified according to persons in whom diabetes developed over a period of 28 years of follow-up and those in whom diabetes did not develop. The minimum genotype score was 7, and the maximum was 27. The P value is for the difference in the mean genotype score between the two groups, accounting for the presence of related persons in the sample. Panel B shows the 28-year cumulative incidence of type 2 diabetes grouped according to whether the genotype score was low (≤15, 41 cases of diabetes among 605 participants at risk), medium (16 to 20, 169 cases among 1562 at risk), or high (≥21, 45 cases among 267 at risk). Overall, among the 2434 participants at risk, 24.9% had a low genotype score, 64.2% had a medium score, and 11.0% had a high score. The P value is for the difference in cumulative incidence across genotype-score groups, accounting for the presence of related persons in the sample. I bars indicate standard errors.