Table 2.

Nested Cox proportional hazard models testing the incidence of cardiovascular disease across quartiles of plasma von Willebrand factor^*

	von Willebrand factor quartile
	1	2			3			4			P value*
Number of CVD events	66	76			84			125
Incidence density (CVD events/100 person year)	0.76	0.89			0.98			1.59
Model 1†	1.00	0.99			0.97			1.42			0.02
		0.71	-	1.38	0.70	-	1.35	1.05	-	1.93
Model 2‡	1.00	0.94			0.98			1.32			0.04
		0.68	-	1.31	0.70	-	1.35	0.97	-	1.80
Model 3A: Model 2 + DM	1.00	0.92			0.99			1.28			0.06
		0.66	-	1.29	0.71	-	1.37	0.94	-	1.74
Model 3B: Model 2 + HOMA-IR	1.00	0.93			0.94			1.21			0.2
		0.67	-	1.29	0.68	-	1.31	0.89	-	1.65
Model 3C: Model 2 + DM + HOMA-IR	1.00	0.92			0.96			1.22			0.1
		0.66	-	1.28	0.69	-	1.33	0.89	-	1.66

^*P values indicate significance of trend across strata of von Willebrand Factor.

^†Hazard ratios with 95% confidence intervals adjusted for age and sex

^‡Hazard ratios adjusted for age, sex, systolic blood pressure, smoking, body mass index, total and HDL cholesterol, treatment with aspirin, insulin, antihypertensive and lipid lowering medication

CVD= cardiovascular disease, DM = type 2 diabetes mellitus, HOMA-IR = insulin resistance measured with the homeostasis model