. Author manuscript; available in PMC: 2009 Sep 21.

Published in final edited form as: J Am Chem Soc. 2008 Nov 26;130(47):15950–15956. doi: 10.1021/ja8046552

Table 1.

G-Quadruplex Stabilization (ΔT_m) Potential by FRET-Melting and Dissociation Constants (K_d) Measured by SPR

Ligand	c-myc (77 ± 1)^a	c-kit2 (71 ± 1)^a	c-kit1 (57 ± 1)^a	dup (58 ± 1)^a
	ΔT_m at 1 μM conc. (°C)
9	2.9	6.0	8.9	0.2
10	7.3	9.2	13.5	0.2
	K_d [μM] and stoichiometry (n)
9	2.68 ± 0.06 (2:1)	4.44 ± 0.55 (2:1)	9.65(0.41(2:1)	nd ^b
10	0.57 ± 0.02 (2:1)	0.69 ± 0.03 (1:1)	3.04(0.08(2:1)	nd ^b

T_m in 60 mM potassium cacodylate buffer, pH 7.4 without ligand.

No significant binding up to 25 μM.