Skip to main content
. Author manuscript; available in PMC: 2009 Sep 21.
Published in final edited form as: Cell. 2006 Dec 1;127(5):1015–1026. doi: 10.1016/j.cell.2006.09.044

Figure 6. Model of Extension of Cas and Signaling at Cell-matrix Contact Sites.

Figure 6

The top and middle panels represent a Cas molecule with unextended configuration of substrate domain in the cytoplasm and with moderate extension of substrate domain at the cell-matrix contact site of spread cells, respectively. The bottom panel represents the extension-dependent phosphorylation of Cas substrate domain by SFK and enhancement of its downstream signaling. SH3 and SB represent the SH3 and the Src-binding domains of Cas, respectively.