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Oxygen saturation (SpO2). Oxygen saturation was measured in room air after removal of doxycycline from 7-week-old conditional surfactant protein (SP)-B mouse (Off Dox). Control mice were maintained under continuous treatment with doxycycline and studied at 7 weeks of age. Removal of doxycycline caused significant decreases in arterial oxygen saturation (n = 10 mice/group). *P < 0.01 versus control. †After 5 days of SP-B deficiency, mice die from respiratory failure.
