Skip to main content
. Author manuscript; available in PMC: 2009 Sep 21.
Published in final edited form as: Life Sci. 2009 Jan 9;84(11-12):380–387. doi: 10.1016/j.lfs.2009.01.001

Fig. 1.

Fig. 1

Selective increase in late INa in R1623Q channels by pCPT-cAMP in the presence of intrapipette fluoride. (A) Normalized whole-cell Na+ current (INa) in response to 2 mM pCPT- cAMP in cells expressing WT (left) or R1623Q (right) channels. Currents were recorded at baseline (0 min) and 10 min after application of pCPT-cAMP. Inset panels show INa at different amplitude (peak INa off scale) and time resolution to emphasize late INa. (B) Time courses of peak and late INa for R1623Q channels in response to pCPT-cAMP. Peak (closed circles) and late (open circles) INa were normalized to the current amplitude at baseline. Application of pCPT-cAMP commenced when the INa become stable (3 min). Late INa amplitude was evaluated by using the mean value of the current amplitude between 39 and 41 ms. Dotted line represents the time course of late INa in the presence of fluoride duplicated from Fig. 2B. (C) The percentage of late INa relative to peak INa of WT and R1623Q channels at baseline and 10 min after application of pCPT-cAMP. Data are mean±SEM. WT (n=5), R1623Q (n=5), *P<0.05.