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Overall effects of fluoride on late INa. (A) Time course of frequency-dependent reduction of the relative amplitude of late INa (peak/late INa) by fluoride in the presence (open symbols) or absence (closed symbols) of PKI (20 μM). (B) Summary data for the relative amplitude of late INa at first pulse and 50th pulse in a train. Data are mean± SEM. fluoride: 1 Hz (n=11), 2 Hz (n=10), +PKI: 1 Hz (n=10), 2 Hz (n=10). *P<0.05.
