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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Drug Discov Today Dis Models. 2008 Fall;5(3):141–146. doi: 10.1016/j.ddmod.2009.02.006

Figure 3.

Figure 3

How mutations that cause human mutations affect Xenopus heart development. Mutations in the Nkx2-5 gene that lead to conduction defects and atrial septal defects in human also cause those defects in Xenopus embryos. Panel A shows how recording and reference electrodes were placed in live embryos that had been injected with mRNA encoding mutant forms of Nkx2-5 to discover if treated embryos developed conduction defects. In Panel B, a cross section of a heart with an abnormal atrial septum in an embryo that had expressed the Nkx2-5. Arrowheads point at the septum.