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Molecular mediators of injury in mice with glomerulonephritis. CD100-deficient mice had lower urinary nitrite excretion and lower intrarenal interleukin (IL)-1β mRNA expression, but intrarenal tumour necrosis factor (TNF) mRNA expression was unchanged. The hatched bars represent values for CD100+/+ and CD100−/− mice immunized with and injected with normal sheep globulin. *P< 0·05, unpaired t-test for IL-1β and TNF; Mann–Whitney test for urinary nitrite.
