Figure 6.

Cell numbers and cellular activation markers expressed on draining lymph node cells in mice immunized with sheep globulin (experiment 2). (a) Compared with CD100^+/+ mice, CD100^−/− mice had fewer B220⁺ cells and B220⁺ CD69⁺ cells. (b) Although the numbers of CD4⁺ and CD69⁺ CD4⁺ cells were similar in wild-type and CD100^−/− splenocytes, CD4⁺ CD25⁺ cells were reduced in CD100^−/− mice and a reduction in CD4⁺ CD44⁺ cells approached statistical significance (P =0·051). **P< 0·01; ***P< 0·0001, unpaired t-test.