Fig. 4.

Migration of differentiated APL cells. (A) Chemotaxis through small pores. Paclitaxel significantly impedes the migration within 3 h of differentiated APL cells through 5-μm large pores (left). There is no statistically significant difference for 12-μm pores (right). Both experiments were performed five times. No change in chemotactic speed of differentiated APL cells could be observed after treatment with paclitaxel on 2D surfaces (B) or in 3D microchannels of 5–7-μm width (C). Data show mean ± SEM.